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Product Description
– Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].
Web ID
– HY-14254A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C14H10N4O
References
– [1]Sugioka M, et al. Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes. Naunyn Schmiedebergs Arch Pharmacol. 1994;350(3):284-293.|[2]Di Paola R, et al. Olprinone, a PDE3 inhibitor, modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats. Eur J Pharmacol. 2011;650(2-3):612-620.
CAS Number
– 106730-54-5
Molecular Weight
– 250.26
SMILES
– CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3
Clinical Information
– Launched
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– PDE1;PDE2;PDE3;PDE4
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
