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Products Details
Product Description
– Olezarsen is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.
Web ID
– HY-153491
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– N/A
References
– [1]Tardif JC, Karwatowska-Prokopczuk E, Amour ES, et al. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J. 2022;43(14):1401-1412.|[2]Karwatowska-Prokopczuk E, Tardif JC, Gaudet D, et al. Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia. J Clin Lipidol. 2022;16(5):617-625.
CAS Number
– 2097587-83-0
Molecular Weight
– N/A
SMILES
– [Olezarsen]
Clinical Information
– Phase 3
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in H2O
Target
– Others
Pathway
– Others
Product type
– Oligonucleotides
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