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Olanzapine
$50 – $70
Products Details
Product Description
– Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].
Web ID
– HY-14541
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H20N4S
References
– [1]Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78.|[2]Karpel-Massler G, et al. Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide’s antiproliferative effect. J Neurooncol. 2015 Mar;122(1):21-33.|[3]Coccurello R, et al. Chronic administration of olanzapine induces metabolic and food intake alterations: a mousemodel of the atypical antipsychotic-associated adverse effects. Psychopharmacology (Berl). 2006 Jul;186(4):561-71.|[4]APPROVED AGREED-UPON LABELING.|[5]Olanzapine for Injection, powder, for solution for intramuscular use.
CAS Number
– 132539-06-1
Molecular Weight
– 312.43
Compound Purity
– 99.83
SMILES
– CC1=CC(C(N2CCN(C)CC2)=N3)=C(S1)NC4=C3C=CC=C4
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 20 mg/mL (ultrasonic)
Target
– 5-HT Receptor;Adrenergic Receptor;Apoptosis;Autophagy;Dopamine Receptor;mAChR;Mitophagy
Isoform
– 5-HT1 Receptor;5-HT2 Receptor;5-HT3 Receptor;5-HT6 Receptor;Dopamine Receptor
Pathway
– Apoptosis;Autophagy;GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
