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Products Details
Product Description
– OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can enable the development of DCAF1-based PROTACs[1].
Web ID
– HY-149935
Shipping
– Room temperature
Molecular Formula
– C19H14Cl2F2N4O2
References
– [1]Alice Shi Ming Li, et al. Discovery of Nanomolar DCAF1 Small Molecule Ligands. J Med Chem. 2023 Apr 13;66(7):5041-5060.
Molecular Weight
– 439.24
SMILES
– O=C(C1=CNN=C1C2=CC=C(Cl)C=C2F)N[C@H](C3=CC=C(F)C(Cl)=C3)CC(N)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ligands for E3 Ligase
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
