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ODN TTAGGG
$600 – $1,800
Products Details
Product Description
– ODN TTAGGG (A151), inhibitory oligonucleotide (ODN), is a TLR9, AIM2 and cGAS antagonist. ODN TTAGGG is immunosuppressive and inhibits AIM2 inflammasome activation, as well as cGAS activation, by competing with DNA. ODN TTAGGG can be used in the study of lupus erythematosus and other related autoimmune diseases. ODN TTAGGG sequence: 5′-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3′[1][2].
Web ID
– HY-150751
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– N/A
References
– [1]John J Kaminski, et al. Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation. J Immunol. 2013 Oct 1;191(7):3876-83.|[2]Folkert Steinhagen, et al. Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes. Eur J Immunol. 2018 Apr;48(4):605-611.
CAS Number
– 1801724-76-4
Molecular Weight
– 7944.30
Compound Purity
– 99.87
SMILES
– [DNA, d(P-thio)(T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G)]
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– H2O : ≥ 20 mg/mL
Target
– AIM2;Toll-like Receptor (TLR)
Pathway
– Immunology/Inflammation
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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