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Obatoclax (Mesylate)
$55 – $475
Products Details
Product Description
– Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2[1][2]. Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity[3][4].
Web ID
– HY-10969
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C21H23N3O4S
Citations
– Am J Cancer Res. 2019 Mar 1;9(3):546-561.|Biomed Pharmacother. 2020 Sep;129:110371.|Cancer Lett. 2022 Nov 30;216028.|iScience. 13 August 2022, 104925.|Norwegian University of Science and Technology. Department of Clinical and Molecular Medicine. 2021 Oct.|Sci Rep. 2019 Sep 24;9(1):13786.|Viruses. 2020 Oct 18;12(10):1178.|ACS Infect Dis. 2023 Oct 5.|Acta Pharmacol Sin. 2021 Aug;42(8):1298-1310.|Departamento de BiotecnologÃa – Departament de Biotecnologia. 2020 Sep 7.
References
– [1]Sulkshane P, et al. BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells. Oncotarget. 2016 Aug 5;8(36):60060-60079.|[2]Ehrenkaufer G, et al. Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity. PLoS Negl Trop Dis. 2020 Mar 20;14(3):e0008150.|[3]Or CR, et al. Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells. Int J Mol Sci. 2016 Dec 27;18(1).|[4]Nguyen M, et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19512-7. Epub 2007 Nov 26.
CAS Number
– 803712-79-0
Molecular Weight
– 413.49
Compound Purity
– 99.74
SMILES
– COC1=CC(C2=CC3=C(C=CC=C3)N2)=N/C1=CC4=C(C=C(N4)C)C.CS(=O)(O)=O
Clinical Information
– Phase 3
Research Area
– Cancer; Infection
Solubility
– DMSO : 12.5 mg/mL (ultrasonic)
Target
– Autophagy;Bcl-2 Family;Parasite
Isoform
– Bcl-2;Bcl-B;Bcl-W;Bcl-xL;Mcl-1
Pathway
– Anti-infection;Apoptosis;Autophagy
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
