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Products Details
Product Description
– Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells[1][2].
Web ID
– HY-138050
Shipping
– Room temperature
Molecular Formula
– C17H16O2
References
– [1]Lim H, et al. (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32(11):1509-14.|[2]Lee HJ, et al. (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. J Enzyme Inhib Med Chem. 2013 Oct;28(5):954-9.|[3]Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66(5):435-8.
CAS Number
– 96895-25-9
Molecular Weight
– 252.31
SMILES
– C=C[C@@H](C1=CC=C(O)C=C1)/C=CC2=CC=C(O)C=C2
Clinical Information
– No Development Reported
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Bacterial;Fungal;Leukotriene Receptor;NO Synthase;Parasite
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation
Product type
– Natural Products
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