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Products Details
Product Description
– NU5455 is a potent, selective, and orally active inhibitor of DNA-PKcs. NU5455 administration increases both the efficacy and the toxicity of a parenterally administered topoisomerase inhibitor. NU5455 enhances the activity of Doxorubicin released locally in liver tumor xenografts without inducing any adverse effect[1].
Web ID
– HY-145427
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C34H33N3O5S
References
– [1]Willoughby CE, et al. Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy. J Clin Invest. 2020;130(1):258-271.
CAS Number
– 1257235-99-6
Molecular Weight
– 595.71
SMILES
– CN(C1=CC=C2SC3=C(C4=C(OC(N5CC(CC6)OC6C5)=CC7=O)C7=CC=C4)C=CC=C3C2=C1)C(CN8CCOCC8)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA-PK
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
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