Download Files:
Products Details
Product Description
– NU223612 is a potent PROTAC (PROTACs) that degrades indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) with a Kd of 640 nM. NU223612 potently degrades the IDO1 protein through CRBN-mediated proteasomal degradation. NU223612 is bound to CRBN with an affinity of 290 nM. NU223612 can cross the blood-brain barrier (BBB)[1].
Web ID
– HY-151886
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C49H55FN6O9
References
– [1]Lakshmi R Bollu, et al. Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma. J Med Chem. 2022 Nov 21.
CAS Number
– 2759420-43-2
Molecular Weight
– 890.99
SMILES
– O=C([C@H](C)[C@@]1([H])CC[C@](C2=CC=NC3=CC=C(F)C=C23)([H])CC1)NC4=CC=C(OC5CCN(C(CCOCCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)CC5)C=C4
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Indoleamine 2,3-Dioxygenase (IDO);PROTACs
Isoform
– Cereblon;IDO1
Pathway
– Metabolic Enzyme/Protease;PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
