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Products Details
Product Description
– NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1].
Web ID
– HY-103381
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C9H7N5
References
– [1]Ortega MA, et al. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg Med Chem. 2002 Jul;10(7):2177-84.
CAS Number
– 40254-90-8
Molecular Weight
– 185.19
SMILES
– NC1=NNC2=NC3=CC=CC=C3N=C21
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK;GSK-3
Isoform
– CDK1;CDK5;GSK-3β
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
