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NSC45586 (sodium)
$125 – $700
Products Details
Product Description
– NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons[1].
Web ID
– HY-19820A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C20H17N6NaO3
References
– [1]Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.
CAS Number
– 6300-44-3
Molecular Weight
– 412.38
Compound Purity
– 98.0
SMILES
– O=C(O[Na])C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– H2O : 5 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– Akt;Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
