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Products Details
Product Description
– NSC45586 is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 can activate AKT in neurons[1].
Web ID
– HY-19820
Shipping
– Room temperature
Molecular Formula
– C20H18N6O3
References
– [1]Jackson TC, et, al. Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes. J Pharmacol Exp Ther. 2013 Nov;347(2):516-28.
CAS Number
– 739301-85-0
Molecular Weight
– 390.40
SMILES
– O=C(O)C1=CC(/N=N/C2=CC=C(/N=N/C3=CC(C)=C(N)C=C3N)C=C2)=CC=C1O
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Akt;Ser/Thr Protease
Pathway
– Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Product type
– Reference compound
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