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NSC-87877
$60 – $600
Products Details
Product Description
– NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2].
Web ID
– HY-18756
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Molecular Formula
– C19H13N3O7S2
References
– [1]Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70.|[2]Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.|[3]Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841.
CAS Number
– 56990-57-9
Molecular Weight
– 459.45
Compound Purity
– 99.0
SMILES
– O=S(C1=C2C=CC=NC2=C(O)C(/N=N/C3=CC=C4C=C(S(=O)(O)=O)C=CC4=C3)=C1)(O)=O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 23.81 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Apoptosis;Phosphatase;SHP2
Pathway
– Apoptosis;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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