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NSC 23766 (trihydrochloride)
$66 – $350
Products Details
Product Description
– NSC 23766 trihydrochloride is an inhibitor of Rac1 activation.
Web ID
– HY-15723A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H38Cl3N7
Citations
– Adv Sci (Weinh). 2021 Mar 8;8(10):2004000.|Am J Physiol Cell Physiol. 2022 Feb 2.|Arch Toxicol. 2022 May 4.|CNS Neurosci Ther. 2021 Feb 3.|Comput Struct Biotec. 2021;19:1933-1943.|Fish Shellfish Immunol. 2022 Aug 3;S1050-4648(22)00414-4.|Food Chem Toxicol. 2020 Dec 24;148:111926.|Food Funct. 2021 Jan 7;12(1):154-161.|Front Immunol. 02 August 2021.|Front Immunol. 2021 Aug 2;12:686846.|Glia. 2023 Apr 26.|J Agric Food Chem. 2021 Oct 25.|J Inorg Biochem. 13 January 2022, 111725.|J Inorg Biochem. 2022 Apr 20;233:111838.|Mol Immunol. 2022 Feb 4;143:135-146.|Bioact Mater. 2021 Jun 1.|Biol Pharm Bull. 2021 Sep 1;44(9):1263-1271.|Cell Death Dis. 2022 Feb 17;13(2):158.|Exp Ther Med. June 7, 2022.|Int Immunopharmacol. 2023 Mar 15;117:110014.|J Cell Commun Signal. 2022 Dec 12.|J Cell Mol Med. 2020 Mar;24(6):3582-3592.|Mol Cell Endocrinol. 16 July 2022, 111719.|Nat Metab. 2022 Dec 19.|Research Square Preprint. 2020 Jul.|Research Square Preprint. 2023 Sep 1.|Vet Microbiol. 2022 Jun;269:109434.
References
– [1]Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39(2):760-7.|[2]Wang Y, et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar;173(5):937-50|[3]Zhao L, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6;6:23972|[4]Song SJ, et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3;6:34415
CAS Number
– 1177865-17-6
Molecular Weight
– 530.96
Compound Purity
– 99.32
SMILES
– NC1=CC(C)=NC2=CC=C(NC3=NC(NC(C)CCCN(CC)CC)=NC(C)=C3)C=C12.[H]Cl.[H]Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 33.33 mg/mL (ultrasonic)|H2O : ≥ 32 mg/mL
Target
– Apoptosis;Ras
Pathway
– Apoptosis;GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
