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Products Details
Product Description
– NS5A-IN-3 (Compound 15) is a potent inhibitor of NS5A. NS5A-IN-3 has extremely high potency against HCV genotype 1b, improved activity against genotype 3a (GT 3a) and good metabolic stability. NS5A-IN-3 exhibits a higher resistance barrier than daclatasvir against genotype 1b[1]. NS5A-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-115982
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C44H44N6O8
References
– [1]Abdallah M, et al. Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier. Eur J Med Chem. 2022;229:114034.
CAS Number
– 2764786-56-1
Molecular Weight
– 784.86
SMILES
– COC(N[C@H](C1=CC=CC=C1)C(N2CCC[C@H]2C(NC3=CC(C#CC4=CC(NC([C@@H]5CCCN5C([C@@H](C6=CC=CC=C6)NC(OC)=O)=O)=O)=CC=C4)=CC=C3)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– HCV Protease
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
