Products Details

Product Description

– NS5A-IN-2 (Compound 33) is a potent inhibitor of NS5A. NS5A-IN-2 has extremely high potency against HCV genotype 1b, improved activity against genotype 3a (GT 3a) and good metabolic stability[1]. NS5A-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Web ID

– HY-115981

Shipping

– Room temperature

Applications

– COVID-19-anti-virus

Molecular Formula

– C46H45N7O7

References

– [1]Abdallah M, et al. Redesigning of the cap conformation and symmetry of the diphenylethyne core to yield highly potent pan-genotypic NS5A inhibitors with high potency and high resistance barrier. Eur J Med Chem. 2022;229:114034.

CAS Number

– 2764786-74-3

Molecular Weight

– 807.89

SMILES

– COC(N[C@H](C1=CC=CC=C1)C(N2CCC[C@H]2C3=NC=C(N3)C4=CC=C(C=C4)C#CC5=CC(NC([C@@H]6CCCN6C([C@@H](C7=CC=CC=C7)NC(OC)=O)=O)=O)=CC=C5)=O)=O

Clinical Information

– No Development Reported

Research Area

– Infection

Solubility

– 10 mM in DMSO

Target

– HCV Protease

Pathway

– Anti-infection;Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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