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NRA-0160
SKU
HY-101641-Get quote
Category Reference compound
Tags 5-HT Receptor;Adrenergic Receptor;Dopamine Receptor, GPCR/G Protein;Neuronal Signaling, Neurological Disease; Endocrinology
Products Details
Product Description
– NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM).
Web ID
– HY-101641
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C24H23F2N3OS
References
– [1]Abekawa T, et al. Effects of NRA0045, a novel potent antagonist at dopamine D4, 5-HT2A, and alpha1 adrenaline receptors, and NRA0160, a selective D4 receptor antagonist, on phencyclidine-induced behavior and glutamate release in rats. Psychopharmacology (Berl). 2003 Sep;169(3-4):247-56. Epub 2003 Jul 31.|[2]Kawashima N, et al. Effects of selective dopamine D4 receptor blockers, NRA0160 and L-745,870, on A9 and A10 dopamine neurons in rats. Life Sci. 1999;65(24):2561-71.
CAS Number
– 204718-47-8
Molecular Weight
– 439.52
SMILES
– O=C(C1=NC(C2=CC=C(F)C=C2)=C(CCN3CC/C(CC3)=CC4=CC=CC(F)=C4)S1)N
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Endocrinology
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor;Adrenergic Receptor;Dopamine Receptor
Isoform
– 5-HT2 Receptor;D3 Receptor;D4 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.