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Nortriptyline (hydrochloride)
SKU
HY-B1417-10mM/1mL
Category Reference compound
Tags Apoptosis;Autophagy;Drug Metabolite, Apoptosis;Autophagy;Metabolic Enzyme/Protease, Cancer; Neurological Disease
$60 – $66
Products Details
Product Description
– Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects[1][2][3].
Web ID
– HY-B1417
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C19H22ClN
References
– [1]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[2]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.|[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.
CAS Number
– 894-71-3
Molecular Weight
– 299.84
Compound Purity
– 99.97
SMILES
– CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C13.[H]Cl
Clinical Information
– Launched
Research Area
– Cancer; Neurological Disease
Solubility
– DMSO : 83.33 mg/mL (ultrasonic)|H2O : 7.14 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Drug Metabolite
Pathway
– Apoptosis;Autophagy;Metabolic Enzyme/Protease
Product type
– Reference compound
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