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nor-NOHA (acetate)
SKU
HY-112885A-10 mg
Category Reference compound
Tags Apoptosis;Arginase, Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease, Cancer; Metabolic Disease; Inflammation/Immunology
$240 – $400
Products Details
Product Description
– nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism[1].
Web ID
– HY-112885A
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C9H20N4O7
References
– [1]Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.
CAS Number
– 1140844-63-8
Molecular Weight
– 296.28
Compound Purity
– 99.0
SMILES
– O=C(O)[C@@H](N)CCNC(NO)=N.CC(O)=O.CC(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Inflammation/Immunology
Solubility
– H2O : 200 mg/mL (ultrasonic)
Target
– Apoptosis;Arginase
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
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