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nor-NOHA (acetate)
$240 – $400
Products Details
Product Description
– nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism[1].
Web ID
– HY-112885A
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C9H20N4O7
References
– [1]Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.
CAS Number
– 1140844-63-8
Molecular Weight
– 296.28
Compound Purity
– 99.0
SMILES
– O=C(O)[C@@H](N)CCNC(NO)=N.CC(O)=O.CC(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Inflammation/Immunology
Solubility
– H2O : 200 mg/mL (ultrasonic)
Target
– Apoptosis;Arginase
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
