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Nolpitantium
$210 – $1,950
Products Details
Product Description
– Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation[1].
Web ID
– HY-108479
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C37H45Cl3N2O2
References
– [1]Emonds-Alt X, et al. In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist. Eur J Pharmacol. 1993 Dec 21;250(3):403-13.
CAS Number
– 153050-21-6
Molecular Weight
– 656.12
SMILES
– O=C(N1C[C@@](CC[N+]2(CC3)CCC3(C4=CC=CC=C4)CC2)(C5=CC=C(Cl)C(Cl)=C5)CCC1)CC6=CC=CC(OC(C)C)=C6.[Cl-]
Clinical Information
– Phase 2
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Neurokinin Receptor
Isoform
– NK1
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
