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NMS-P715
$90 – $1,680
Products Details
Product Description
– NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.
Web ID
– HY-12382
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C35H39F3N8O3
References
– [1]Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64.|[2]Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315.
CAS Number
– 1202055-32-0
Molecular Weight
– 676.73
Compound Purity
– 99.58
SMILES
– O=C(C1=NN(C)C2=C1CCC3=CN=C(NC4=CC=C(C(NC5CCN(C)CC5)=O)C=C4OC(F)(F)F)N=C23)NC6=C(CC)C=CC=C6CC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 2 mg/mL (ultrasonic)
Target
– Mps1
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
