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NMS-P118
$84 – $1,740
Products Details
Product Description
– NMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy.
Web ID
– HY-18954
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H24F3N3O2
References
– [1]Papeo G, et al. Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy. J Med Chem. 2015 Sep 10;58(17):6875-98.
CAS Number
– 1262417-51-5
Molecular Weight
– 395.42
Compound Purity
– 99.78
SMILES
– FC(CC1)(F)CCC1N(CC2)CCC2N(C3=O)CC4=C3C(C(N)=O)=CC(F)=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 16 mg/mL (ultrasonic;warming)
Target
– PARP
Isoform
– PARP1;PARP2
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
