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Products Details
Product Description
– NMDA receptor antagonist 6 (compound 13b) is an antagonist of NMDA receptor, targeting to the glycine binding site. NMDA receptor antagonist 6 shows cytoneuroprotective potency, and protects PC12 cells against NMDA-induced injury and cell apoptosis[1].
Web ID
– HY-155049
Shipping
– Room temperature
Molecular Formula
– C25H23NO2
References
– [1]Yang L, et al. Design, synthesis and evaluation of novel 1-phenyl-pyrrolo [1, 2-b] isoquinolin-3-one derivatives as antagonists for the glycine binding site of the NMDA receptor[J]. European Journal of Medicinal Chemistry, 2023: 115624.
Molecular Weight
– 369.46
SMILES
– O=C1N2CC3=CC=CC=C3CC2C(C4=CC(OCC5=CC=CC=C5)=CC=C4)C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– iGluR
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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