Download Files:
NLRP3-IN-NBC6
$360
Only 1000 item(s) left in stock.
Products Details
Product Description
– NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs)[1].
Web ID
– HY-131040
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H16BCl3N2O2
References
– [1]Baldwin AG, et al. Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem Biol. 2017;24(11):1321-1335.e5.
CAS Number
– 2068818-02-8
Molecular Weight
– 409.50
Compound Purity
– 99.40
SMILES
– CC(C1=C(N[B-](C2=CC=CC=C2)([O+]=C1N)C3=CC=CC=C3)C(Cl)(Cl)Cl)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NOD-like Receptor (NLR)
Isoform
– NLRP3
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
