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Products Details
Product Description
– NLRP3-IN-21 (compound L38) is a NLRP3 inflammasome inhibitor with inflammatory properties. NLRP3-IN-21 inhibits NLRP3 inflammasome activation and pyroptosis by suppressing gasdermin D cleavage, ASC oligomerization, and NLRP3 inflammasome assembly[1].
Web ID
– HY-149604
Shipping
– Room temperature
Molecular Formula
– C20H13Cl2F3N6O2S
References
– [1]Na Li, et al. Discovery of Triazinone Derivatives as Novel, Specific, and Direct NLRP3 Inflammasome Inhibitors for the Treatment of DSS-Induced Ulcerative Colitis. J Med Chem. 2023 Oct 12;66(19):13428-13451.
CAS Number
– 2956791-61-8
Molecular Weight
– 529.32
SMILES
– O=C1N(N=C(N2C1=CC3=C2C=C(S3)Cl)C(C)C)CC4=NN=C(O4)C5=CC=C(N=C5Cl)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NOD-like Receptor (NLR)
Pathway
– Immunology/Inflammation
Product type
– Reference compound
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