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Products Details
Product Description
– Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of aldehyde dehydrogenase (ALDH), an enzyme involved in the metabolism of alcohol.
Web ID
– HY-107030
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C10H8N4O4
References
– [1]Koda LY, Madamba SG, Bloom FE. Hypotensive response of ethanol in rats pretreated with disulfiram or nitrefazole. Life Sci. 1984;35(16):1659-1665. |[2]Zorzano A, Herrera E. Differences in the kinetic properties and sensitivity to inhibitors of human placental, erythrocyte, and major hepatic aldehyde dehydrogenase isoenzymes. Biochem Pharmacol. 1990;39(5):873-878.
CAS Number
– 21721-92-6
Molecular Weight
– 248.19
SMILES
– CC1=NC([N+]([O-])=O)=CN1C2=CC=C([N+]([O-])=O)C=C2
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Aldehyde Dehydrogenase (ALDH)
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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