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Products Details
Product Description
– Ninerafaxstat (IMB-1018972) is a cardiac mitotrope agent. Ninerafaxstat increases myocardial metabolic efficiency by shifting substrate utilization towards glucose through reducing fatty acid oxidation (inhibiting 3-ketoacyl CoA thiolase)[1].
Web ID
– HY-139577
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H29N3O5
References
– [1]Larry Tremaine, et al. Abstract 10372: A Clinical Drug-Drug Interaction Study of Imb-1018972, a Novel Investigational Cardiac Mitotrope in Phase 2 Development for the Treatment of Myocardial Ischemia and Hypertrophic Cardiomyopathy. METABOLISM AND PHYSIOLOGY. 8 Nov 2021.
CAS Number
– 2254741-41-6
Molecular Weight
– 415.48
SMILES
– O=C(C1=CC=CN=C1)OCCN2CCN(CC2)CC3=CC=C(C(OC)=C3OC)OC
Clinical Information
– Phase 2
Research Area
– Cancer; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Mitochondrial Metabolism
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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