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Products Details
Product Description
– Ninerafaxstat (IMB-1018972) is a cardiac mitotrope agent. Ninerafaxstat increases myocardial metabolic efficiency by shifting substrate utilization towards glucose through reducing fatty acid oxidation (inhibiting 3-ketoacyl CoA thiolase)[1].
Web ID
– HY-139577
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H29N3O5
References
– [1]Larry Tremaine, et al. Abstract 10372: A Clinical Drug-Drug Interaction Study of Imb-1018972, a Novel Investigational Cardiac Mitotrope in Phase 2 Development for the Treatment of Myocardial Ischemia and Hypertrophic Cardiomyopathy. METABOLISM AND PHYSIOLOGY. 8 Nov 2021.
CAS Number
– 2254741-41-6
Molecular Weight
– 415.48
SMILES
– O=C(C1=CC=CN=C1)OCCN2CCN(CC2)CC3=CC=C(C(OC)=C3OC)OC
Clinical Information
– Phase 2
Research Area
– Cancer; Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Mitochondrial Metabolism
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
