Products Details

Product Description

– Nifedipine-d4 is the deuterium labeled Nifedipine. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

Web ID

– HY-B0284S1

Shipping

– Room temperature

Molecular Formula

– C17H14D4N2O6

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Ratre MS, et al. Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. J Indian Soc Periodontol. 2016 Jul-Aug;20(4):396-401.|[3]Yu SS, et al. Nifedipine Increases Iron Content in WKPT-0293 Cl.2 Cells via Up-Regulating Iron Influx Proteins. Front Pharmacol. 2017 Feb 13;8:60|[4]Carvajal JA, et al. The Synergic In Vitro Tocolytic Effect of Nifedipine Plus Ritodrine on Human Myometrial Contractility. Reprod Sci. 2017 Apr;24(4):635-640.|[5]Liu P, et al. The L-type Ca(2+) Channel Blocker Nifedipine Inhibits Mycelial Growth, Sporulation, and Virulence of Phytophthora capsici. Front Microbiol. 2016 Aug 4;7:1236.

CAS Number

– 1219798-99-8

Molecular Weight

– 350.36

SMILES

– COC(C1=C(C)NC(C)=C(C(OC)=O)C1C2=C(C([2H])=C([2H])C([2H])=C2[2H])[N+]([O-])=O)=O

Clinical Information

– No Development Reported

Research Area

– Cardiovascular Disease; Cancer

Solubility

– 10 mM in DMSO

Target

– Autophagy;Calcium Channel;Isotope-Labeled Compounds

Pathway

– Autophagy;Membrane Transporter/Ion Channel;Neuronal Signaling;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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