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Nicotinamide-13C6
$1,850
Only 1000 item(s) left in stock.
Products Details
Product Description
– Nicotinamide-13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
Web ID
– HY-B0150S2
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– 13C6H6N2O
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Bhansali SG, et al. Nicotinamide prevents apoptosis in human cortical neuronal cells. Toxicol Mech Methods. 2006;16(4):173-80.|[3]Peck B, et al. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther. 2010 Apr;9(4):844-55.|[4]Fushima T, et al. Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure. Am J Physiol Renal Physiol. 2016 Dec 7:ajprenal.00501.2016|[5]Roslan J, et al. Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. Biomed Pharmacother. 2016 Dec 24;86:570-582|[6]Suzuki E, et al. Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life Sci. 2010 Apr 24;86(17-18):676-82.
CAS Number
– 2749910-55-0
Molecular Weight
– 128.08
SMILES
– O=[13C]([13C]1=[13CH][13CH]=[13CH]N=[13CH]1)N
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Cancer
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite;Sirtuin
Pathway
– Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
