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Product Description
– Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells[2][3][5].
Web ID
– HY-B0497B
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C13H10Cl2N2O5
References
– [1]P Andrews, et al. The biology and toxicology of molluscicides, Bayluscide. Pharmacol Ther. 1982;19(2):245-95.|[2]Wei Chen, et al. Niclosamide: Beyond an antihelminthic drug. Cell Signal. 2018 Jan;41:89-96.|[3]Kei Satoh, et al. Identification of Niclosamide as a Novel Anticancer Agent for Adrenocortical Carcinoma. Clin Cancer Res. 2016 Jul 15;22(14):3458-66.|[4]Xiaomei Ren, et al. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9.|[5]Chang-Jer Wu, et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48(7):2693-6.
CAS Number
– 73360-56-2
Molecular Weight
– 345.13
SMILES
– O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O.O
Clinical Information
– Launched
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Parasite;STAT
Isoform
– STAT3
Pathway
– Anti-infection;JAK/STAT Signaling;Stem Cell/Wnt
Product type
– Reference compound
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