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Product Description
– Niacin-15N,13C3 is the 13C and 15N labeled Niacin[1]. Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases[2][3].
Web ID
– HY-B0143S4
Shipping
– Room temperature
Molecular Formula
– C3 13C3H5 15NO2
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010 Jun;210(2):353-61.|[3]Wan P, et al. Pellagra: a review with emphasis on photosensitivity. Br J Dermatol. 2011 Jun164(6):1188-200.|[4]Ishii N, et al. Pellagra among chronic alcoholics: clinical and pathological study of 20 necropsy cases. J Neurol Neurosurg Psychiatry. 1981 Mar44(3):209-15.|[5]Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18.|[6]Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar69(3):653-8.|[7]Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25103(17):6682-7.
CAS Number
– 2483829-87-2
Molecular Weight
– 127.08
SMILES
– O[13C](C1=[13CH][15N]=[13CH]C=C1)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Autophagy;Endogenous Metabolite
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
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