Download Files:
Products Details
Product Description
– NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin。NHEJ inhibitor-1 also induces ROS generation and MMP deduction[1].
Web ID
– HY-146194
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H35N7O8PtS
References
– [1]Xing Wang, et al. A trifunctional Pt(II) complex alleviates the NHEJ/HR-related DSBs repairs to evade cisplatin-resistance in NSCLC. Bioorg Chem. 2020 Nov;104:104210.
Molecular Weight
– 848.79
SMILES
– [H][C@]12CS[C@H]([C@]1(NC(N2)=O)[H])CCCCC(NCCN3C(C4=CC=CC5=C4C(C3=O)=CC=C5/N=C6CC7(C(O[Pt]([NH3])(OC7=O)[NH3])=O)C/6)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Reactive Oxygen Species
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
