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Products Details
Product Description
– NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats[1].
Web ID
– HY-151360
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C16H16Cl2N2O2S
References
– [1]Jacobs JW, et al. Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3. ACS Med Chem Lett. 2022 Apr 11;13(7):1043-1051.
CAS Number
– 543734-50-5
Molecular Weight
– 371.28
SMILES
– CN1CC2=C(C(C1)C3=CC(S(N)(=O)=O)=CC=C3)C=C(C=C2Cl)Cl
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Sodium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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