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Product Description
– NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form[1]. NHC-triphosphate is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2].
Web ID
– HY-135867
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C9H16N3O15P3
Citations
– ACS Bio Med Chem Au. October 24, 2022.|Commun Biol. 2022 Feb 22;5(1):154.|J Biol Chem. 2021 May 11;100770.|Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.|ACS Sens. 2022 May 27;7(5):1564-1571.
References
– [1]Stuyver LJ,et al. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.Antimicrob Agents Chemother. 2003 Jan;47(1):244-54.|[2]Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
CAS Number
– 34973-27-8
Molecular Weight
– 499.16
Compound Purity
– 99.80
SMILES
– O[C@H]1[C@H](N(C=C/C2=N/O)C(N2)=O)O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@H]1O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– H2O : 160 mg/mL (ultrasonic)
Target
– Endogenous Metabolite;Enterovirus;HCV;SARS-CoV;Topoisomerase
Pathway
– Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
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