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NF546
SKU
HY-108661-Get quote
Category Reference compound
Tags GPCR/G Protein, Inflammation/Immunology, P2Y Receptor
Products Details
Product Description
– NF546 is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells[1].
Web ID
– HY-108661
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C47H44N6Na4O17P4
References
– [1]Meis S, et al. NF546 [4,4′-(carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-alpha,alpha’-diphosphonic acid) tetrasodium salt] is a non-nucleotide P2Y11 agonist and stimulates release of interleukin-8 from human monocyte-derived dendritic cells. J Pharmacol Exp Ther. 2010 Jan;332(1):238-47.
CAS Number
– 1006028-37-0
Molecular Weight
– 1180.74
SMILES
– O=P(O)(O[Na])CC1=C(C=CC(CP(O)(O[Na])=O)=C1)NC(C2=CC(NC(C3=CC(NC(NC4=CC(C(NC5=CC(C(NC6=C(C=C(CP(O)(O[Na])=O)C=C6)CP(O)(O[Na])=O)=O)=CC=C5C)=O)=CC=C4)=O)=CC=C3)=O)=C(C)C=C2)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– P2Y Receptor
Isoform
– P2Y11 Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
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