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NF023 (hexasodium)
$280 – $450
Products Details
Product Description
– NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively[1][2][3][4].
Web ID
– HY-108676
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C35H20N4Na6O21S6
References
– [1]F Soto, et al. Antagonistic Properties of the Suramin Analogue NF023 at Heterologously Expressed P2X Receptors. Neuropharmacology. 1999 Jan;38(1):141-9.|[2]M Freissmuth, et al. Suramin Analogues as Subtype-Selective G Protein Inhibitors. Mol Pharmacol. 1996 Apr;49(4):602-11.|[3]G Lambrecht, et al. Agonists and Antagonists Acting at P2X Receptors: Selectivity Profiles and Functional Implications. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):340-50.|[4]M Silva-Ramos, et al. Activation of Prejunctional P2x2/3 Heterotrimers by ATP Enhances the Cholinergic Tone in Obstructed Human Urinary Bladders. J Pharmacol Exp Ther. 2020 Jan;372(1):63-72.
CAS Number
– 104869-31-0
Molecular Weight
– 1162.88
Compound Purity
– 99.0
SMILES
– O=C(C1=CC(NC(NC2=CC(C(NC(C(C([S](=O)(O[Na])=O)=C3)=C4C=C3[S](=O)(O[Na])=O)=CC=C4[S](=O)(O[Na])=O)=O)=CC=C2)=O)=CC=C1)NC(C(C([S](=O)(O[Na])=O)=C5)=C6C=C5[S](=O)(O[Na])=O)=CC=C6[S](=O)(O[Na])=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– H2O : ≥ 116.3 mg/mL
Target
– P2X Receptor
Isoform
– P2X1 Receptor
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
