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Products Details
Product Description
– NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase[1].
Web ID
– HY-147682
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H27N3O4
References
– [1]Jia X, et al. Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones. Bioorg Med Chem. 2020 Jul 1;28(13):115557.
CAS Number
– 2425675-52-9
Molecular Weight
– 409.48
SMILES
– O=C(N/N=C/C1=C/CC[C@]2(C)[C@@]([C@@]([C@](CC1)([H])C3=C)([H])OC3=O)([H])O2)NC4=CC=C(C)C=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;NF-κB
Pathway
– Apoptosis;NF-κB
Product type
– Reference compound
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