Products Details

Product Description

– NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay[1].

Web ID

– HY-155998

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C19H18O5

References

– [1]Wu Y, et al. Cantharidin analogue alleviates dextran sulfate sodium-induced colitis in mice by inhibiting the activation of NF-κB signaling. Eur J Med Chem. 2023 Nov 15;260:115731.

CAS Number

– 2768833-35-6

Molecular Weight

– 326.34

SMILES

– O=C(C1=C(C2OC1CC2C#CC3=CC=C(C)C=C3)C(OC)=O)OC

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– 10 mM in DMSO

Target

– NF-κB

Pathway

– NF-κB

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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