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Product Description
– Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model[1].
Web ID
– HY-117133
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C23H27F2N5O4
References
– [1]Askew BC, et, al. Ocular Distribution and Pharmacodynamics of SF0166, a Topically Administered αvβ3 Integrin Antagonist, for the Treatment of Retinal Diseases. J Pharmacol Exp Ther. 2018 Aug;366(2):244-250.
CAS Number
– 1621332-91-9
Molecular Weight
– 475.49
SMILES
– OC(C[C@@H](C1=CN=C(OC(F)F)C=C1)N2C(N(CCCC(N3)=CC=C4C3=NCCC4)CC2)=O)=O
Clinical Information
– Phase 2
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Integrin
Isoform
– αvβ3;αvβ6;αvβ8
Pathway
– Cytoskeleton
Product type
– Reference compound
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