Download Files:
Nenocorilant
$580 – $3,000
Products Details
Product Description
– Nenocorilant (Relacorilant) is a potent, orally activity glucocorticoid receptor (GR) antagonist with Ki value of 0.15 nM. Nenocorilant has pro-apoptotic effects and improves potency combined with cytotoxic agent. Nenocorilant can be used for cancer research[1][2][3].
Web ID
– HY-147293
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H21F4N7O3S
References
– [1]Greenstein AE, et, al. Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells. Oncotarget. 2021 Jun 22;12(13):1243-1255.|[2]Stringer-Reasor EM, et, al. Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma. Gynecol Oncol. 2015 Sep;138(3):656-62.|[3]WHO Drug Information. International Nonproprietary Names for Pharmaceutical
CAS Number
– 1496509-78-4
Molecular Weight
– 587.55
Compound Purity
– 99.72
SMILES
– O=C(C1=CC(C(F)(F)F)=CC=N1)[C@@]23C(CCN(C3)S(=O)(C4=NN(N=C4)C)=O)=CC5=C(C=NN5C6=CC=C(C=C6)F)C2
Clinical Information
– Phase 3
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Caspase;Glucocorticoid Receptor
Pathway
– Apoptosis;Immunology/Inflammation;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
