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Nelfinavir (Mesylate)
$60 – $320
Products Details
Product Description
– Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent[1][2][3].
Web ID
– HY-15287A
Storage Temperature
– 4°C (Powder, stored under nitrogen)
Shipping
– Room Temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C33H49N3O7S2
Citations
– bioRxiv. 2021 Feb 1.|Cell Signal. 2020 Nov;75:109775.|Cells. 2022, 11(22), 3580|Nat Commun. 2020 Sep 4;11(1):4417.|Signal Transduct Target Ther. 2021 May 29;6(1):212.|Viruses. 2022, 14(7), 1369.|Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00872-20.|Antiviral Res. 2022 Jun;202:105311.|bioRxiv. 2020 May.|Int J Antimicrob Agents. 2019 Dec;54(6):814-819.|J Med Chem. 2021 Mar 11;64(5):2725-2738.|PLoS One. 2015 Aug 11;10(8):e0134707.
References
– [1]Bono C, et al. The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo. Haematologica. 2012;97(7):1101‐1109.|[2]Mondal D, et al. Nelfinavir suppresses signaling and nitric oxide production by human aortic endothelial cells: protective effects of thiazolidinediones. Ochsner J. 2013 Spring;13(1):76-90.|[3]Kaldor SW, et al. Nelfinavir mesylate (AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. J Med Chem. 1997 Nov 21;40(24):3979-85.|[4]Gills JJ, et al. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that inducesendoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo. Clin Cancer Res. 2007 Sep 1;13(17):5183-94.|[5]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.
CAS Number
– 159989-65-8
Molecular Weight
– 663.89
Compound Purity
– 98.93
SMILES
– [H][C@]12C[C@@H](C(NC(C)(C)C)=O)N(C[C@H]([C@@H](NC(C3=C(C)C(O)=CC=C3)=O)CSC4=CC=CC=C4)O)C[C@@]1([H])CCCC2.CS(=O)(O)=O
Clinical Information
– Launched
Research Area
– Cancer; Infection
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– HIV;HIV Protease
Isoform
– HIV-1
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
