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Necrostatin-5
SKU
HY-124546-10 mg
Category Reference compound
Tags Apoptosis, Necroptosis;RIP kinase, Neurological Disease
$50 – $180
Products Details
Product Description
– Necrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 µM. Necrostatin-5 also is a RIP1 inhibitor. Necrostatin-5 shows cardioprotective effects[1][2][3].
Web ID
– HY-124546
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C19H17N3O2S2
References
– [1]Wang K, et al. Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1455-65. |[2]Dmitriev YV, et al. Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion. Bull Exp Biol Med. 2013 Jun;155(2):245-8.|[3]González-Juarbe N, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015 Dec 11;11(12):e1005337.
CAS Number
– 337349-54-9
Molecular Weight
– 383.49
Compound Purity
– 98.43
SMILES
– O=C(N1C2=CC=C(C=C2)OC)C3=C(N=C1SCC#N)SC4=C3CCCC4
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Necroptosis;RIP kinase
Isoform
– RIPK1
Pathway
– Apoptosis
Product type
– Reference compound
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