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Nebicapone
$300 – $2,250
Products Details
Product Description
– Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson’s disease[1].
Web ID
– HY-106405
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C14H11NO5
References
– [1]Loureiro AI, et al. Human metabolism of nebicapone (BIA 3-202), a novel catechol-o-methyltransferase inhibitor: characterization of in vitro glucuronidation. Drug Metab Dispos. 2006 Nov;34(11):1856-62.
CAS Number
– 274925-86-9
Molecular Weight
– 273.24
Compound Purity
– 99.61
SMILES
– O=C(C1=CC([N+]([O-])=O)=C(O)C(O)=C1)CC2=CC=CC=C2
Clinical Information
– Phase 2
Research Area
– Metabolic Disease
Solubility
– DMSO : ≥ 100 mg/mL
Target
– COMT
Pathway
– Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
