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Products Details
Product Description
– ND-2158 is a competitive IRAK4 inhibitor, with the Ki of 1.3 nM. ND-2158 suppresses LPS-induced TNF production in human white blood cells, alleviated collagen-induced arthritis, and blocked gout formation in mouse models. ND-2158 has antitumor activity in vivo[1].
Web ID
– HY-120041
Shipping
– Room temperature
Molecular Formula
– C22H30N4O4S
References
– [1]Kelly PN, et al. Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy. J Exp Med. 2015;212(13):2189-2201.
CAS Number
– 1388896-07-8
Molecular Weight
– 446.56
SMILES
– O=C(N)[C@@H](O)C[C@H]1CCC2=C1C3=C(O[C@@H]4CC[C@@H](N5CCOCC5)CC4)N=CN=C3S2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– IRAK
Pathway
– Immunology/Inflammation
Product type
– Reference compound
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