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Products Details
Product Description
– NC-R17 is a RSL3-based noncovalent GPX4 degrader, involving in Ferroptosis. NC-R17 exhibits anti-tumor activity, used for noncovalent GPX4 PROTACs design[1].
Web ID
– HY-155075
Shipping
– Room temperature
Molecular Formula
– C53H67N7O7
References
– [1]Zheng C, et al. Structure-activity relationship study of RSL3-based GPX4 degraders and its potential noncovalent optimization. Eur J Med Chem. 2023 Jul 5;255:115393.
Molecular Weight
– 914.14
SMILES
– O=C(OC)[C@@H]1N(C(CC)=O)[C@@H](C2=CC=C(C(N3CCN(CCCCCCCCCCCCCNC4=C(CN(C5C(NC(CC5)=O)=O)C6=O)C6=CC=C4)CC3)=O)C=C2)C7=C(C(C=CC=C8)=C8N7)C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ferroptosis;Glutathione Peroxidase
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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