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Products Details
Product Description
– NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation. NBI-961 induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells[1].
Web ID
– HY-156437
Shipping
– Room temperature
Molecular Formula
– C28H27F3N6O2S
References
– [1]Mason McCrury, et al. Bifunctional inhibitor reveals NEK2 as a therapeutic target and regulator of oncogenic pathways in lymphoma. Mol Cancer Ther. 2023 Oct 11.
CAS Number
– 2225902-98-5
Molecular Weight
– 568.61
SMILES
– CC(C1=C(C=CC=C1)C(F)(F)F)OC2=C(SC(C3=CN=C4C=C(C=CN34)C5=CN(CCN(C)C)N=C5)=C2)C(N)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Ser/Thr Protease
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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