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Nargenicin A1
$578 – $1,735
Products Details
Product Description
– Nargenicin A1 is an antibiotic agent against various Gram-positive bacteria. Nargenicin A1 shows anti-inflammatory activity. Nargenicin A1 protects HINAE cells against Tacrolimus (HY-13756)-induced DNA damage and apoptosis. Nargenicin A1 can also be used for the research of acute myeloid leukemia[1].
Web ID
– HY-123121
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C28H37NO8
References
– [1]Dhakal D, et al. Characterization of Tailoring Steps of Nargenicin A1 Biosynthesis Reveals a Novel Analogue with Anticancer Activities. ACS Chem Biol. 2020 Jun 19;15(6):1370-1380.|[2]Da Hye Kwon, et al. Nargenicin A1 attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB signaling pathway. EXCLI J. 2021 May 28;20:968-982.
CAS Number
– 70695-02-2
Molecular Weight
– 515.60
SMILES
– C/C([C@]12O[C@@H]([C@@H]([C@@H]([C@H]([C@]32[H])O)C)OC(C4=CC=CN4)=O)[C@]3([H])C=C[C@]1([H])C[C@@H]5OC)=C[C@H]([C@]([H])(OC5=O)[C@H](O)C)C
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Apoptosis;Bacterial;NF-κB
Pathway
– Anti-infection;Apoptosis;NF-κB
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
