Naftopidil-d5

$919

Only 1000 item(s) left in stock.

Products Details

Product Description

– Naftopidil-d5 is deuterium labeled Naftopidil. Naftopidil (KT-611) is is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects. Naftopidil can be used for the research of prostate hyperplasia[1][2].

Web ID

– HY-B0391S1

Shipping

– Room temperature

Applications

– Metabolism-protein/nucleotide metabolism

Molecular Formula

– C24H23D5N2O3

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]R Takei, et al. Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol. 1999 Apr;79(4):447-54.|[3]Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.

CAS Number

– 2747918-58-5

Molecular Weight

– 397.52

SMILES

– OC(C([2H])([2H])N1CCN(CC1)C2=C(OC)C=CC=C2)([2H])C([2H])([2H])OC3=CC=CC4=C3C=CC=C4

Clinical Information

– No Development Reported

Research Area

– Cardiovascular Disease; Endocrinology

Solubility

– 10 mM in DMSO

Target

– Adrenergic Receptor;Isotope-Labeled Compounds

Pathway

– GPCR/G Protein;Neuronal Signaling;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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