Nabumetone-d3

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Products Details

Product Description

– Nabumetone-d3 is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.

Web ID

– HY-B0559S

Shipping

– Room temperature

Molecular Formula

– C15H13D3O2

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46(5):753-6.|[3]Melarange R, et al. Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid): comparison with indomethacin. Agents Actions. 1992;Spec No:C82-3.

CAS Number

– 1216770-08-9

Molecular Weight

– 231.30

SMILES

– CC(CCC1=CC2=C(C=C1)C=C(C=C2)OC([2H])([2H])[2H])=O

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology; Cancer

Solubility

– 10 mM in DMSO

Target

– COX;Isotope-Labeled Compounds

Pathway

– Immunology/Inflammation;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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