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Products Details
Product Description
– N-Boc-SBP-0636457-OH, a ligand for E3 ubiquitin ligase, is used in the recruitment of IAP E3 ligases. N-Boc-SBP-0636457-OH can be connected to the ligand for Bcl-xL by a linker to form PROTAC Bcl-xL degrader-1 (HY-131188).
Web ID
– HY-131189
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H44N4O7
References
– [1]Zhang X, et al. Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines. Eur J Med Chem. 2020;199:112397.
Molecular Weight
– 572.69
SMILES
– O=C(N[C@@H]1CCCC2=C1C=CC(O)=C2)[C@@H]3C(C)(C[C@@]([H])(N3C4=O)OCC[C@@H]4NC([C@@H](N(C)C(OC(C)(C)C)=O)C)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Ligands for E3 Ligase
Isoform
– IAP
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
